SHORT
COMMUNICATION
Advanced
Glycation End Products and Nutrition
M.
KRAJČOVIČOVÁ-KUDLÁČKOVÁ, K. ŠEBEKOVÁ, R.
SCHINZEL1,
J. KLVANOVÁ
Institute of Preventive and Clinical Medicine,
Bratislava, Slovak Republic and 1Institute of
Physiological Chemistry, University of Würzburg, Würzburg, Germany
Received June 27, 2001
Accepted September 26, 2001
Summary
Advanced glycation end products (AGEs)
may play an important adverse role in process of
atherosclerosis, diabetes, aging and chronic
renal failure. Levels of Ne-carboxymethyllysine
and fluorescent AGE values were estimated in two
nutritional population groups - alternative group
(vegetarians - plant food, milk products, eggs)
and traditional group (omnivorous subjects).
Vegetarians have a significantly higher
carboxymethyllysine content in plasma and
fluorescent AGE values. Intake of proteins,
lysine and monosaccharides as well as culinary
treatment, consumption of food AGEs (mainly from
technologically processed products) and the
routes of Maillard reaction in organism are the
substantial sources of plasma AGEs. Vegetarians
consume less proteins and saccharides. Lysine
intake is significantly reduced (low content in
plant proteins). Subjects on alternative
nutrition do not use high temperature for
culinary treatment and consume low amount of
technologically processed food. Fructation
induced AGE fluorescence is greater as compared
with that induced by glucose. It is due to higher
participation of a more reactive acyclic form of
fructose. Intake of vegetables and fruit with
predominance of fructose is significantly higher
in vegetarians. Comparison of nutrition and
plasma AGEs in vegetarian and omnivorous groups
shows that the higher intake of fructose in
alternative nutrition of healthy subjects may
cause an increase of AGE levels.
Key
words
Ne-carboxymethyllysine
· Fructose · Vegetarian diet · Advanced
glycation end products
Reprint
requests
M. Kudláčková, Ph.D., Institute of Preventive
and Clinical Medicine, Limbová 14, SK-833 01
Bratislava, Slovak Republic
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