Mathematical
Model of the Electromechanical Heart Contractile
System - Regulatory Subsystem Physiological
Considerations
M. MLČEK, J. NEUMANN,
O. KITTNAR, V. NOVÁK
Institute of Physiology, First Faculty
of Medicine, Charles University, Prague, Czech
Republic
Received October 25,
2000
Accepted January 11, 2001
Summary
The
biochemical model of excitation-contraction
coupling in cardiomyocyte is presented and the
validity of simulations of both physiological and
pathological processes is discussed. The model of
regulatory and actomyosin subsystems, even if it
is rather simple in its regulatory subunit, gives
results well consistent with experimental data.
Specifically, intracellular free calcium levels
([Ca2+]i) were computed under various states of
sarcoendoplasmic reticular Ca2+-ATPase (SERCA2)
and compared to experimental findings. Computed
results reproduced well both the increase in
resting [Ca2+]i level and the attenuation of
[Ca2+]i decline commonly observed in heart
failure. Thus the computational simulations could
help to identify core relations in studied
systems by comparing results obtained using
similar models of various complexities.
Key
words
Myocardial
contraction · Excitation-contraction coupling ·
Simulations
Reprint
requests
M.
Mlček, Institute of Physiology, Charles
University, Albertov 5, 120 00 Prague 2, Czech
Republic. E-mail: mikulas.mlcek@lf1.cuni.cz
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